Evidence that the stalk of Drosophila kinesin heavy chain is an alpha-helical coiled coil.
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Evidence that the stalk of Drosophila kinesin heavy chain is an alpha- helical coiled coil
Kinesin is a mechanochemical enzyme composed of three distinct domains: a globular head domain, a rodlike stalk domain, and a small globular tail domain. The stalk domain has sequence features characteristic of alpha-helical coiled coils. To gain insight into the structure of the kinesin stalk, we expressed it from a segment of the Drosophila melanogaster kinesin heavy chain gene and purified i...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1992
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.116.4.957